Clooney received a Best Actor nomination for Up In The Air Photo: Paramount Pictures
Chairman of the AFI Board of Trustees Sir Howard Stringer said: "George Clooney is America's leading man. Director, producer, writer and actor - a modern-day screen icon who combines the glamour of a time gone by with a ferocious passion for ensuring art's impact echoes beyond the screen. AFI is proud to present him with its 46th Life Achievement Award."
Clooney is no stranger to accolades. He won an Oscar for Best Supporting Actor for Syriana and received Best Actor nominations for Michael Clayton, Up In The Air and The Descendants. He has also received plaudits for his directing and writing, receiving Academy Award nominations for Good Night And Good Luck and The Ides Of March. He earned a Best Picture Oscar for producing Argo.
Other recent recipients of the award include Jane Fonda, Diane Keaton, Mel Brooks and John Williams.